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Lacking a known etiology makes rapid evaluation and treatment difficult, with liver transplantation often considered as the only therapeutic option Common variants at 6p21.32 were associated with ia among the common variants, five snps at the hla region passed the criteria in our discovery stage (p < 1 × 10 −4, see material and methods, figure 1). Our study identified and validated two common variants and three rare variants associated with ia in immunologic and neurological genes, providing new insight into the etiology of ia.

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