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Trastuzumab binding to her2 prevents homodimerization or heterodimerization (her2/her3) of the receptor, ultimately inhibiting the activation of mapk and pi3k/akt cellular signalling pathways. Rrently being evaluated as adjuvant treatment for early breast cancer Dm1 binds to tubulin in microtubules and inhibits microtubule function producing cell arrest and apoptosis

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Trastuzumab emtansine binds to human epidermal growth factor 2 (her2) receptors and undergoes internalization and lysosomal degradation, resulting in increased targeted delivery of dm1 to malignant cells that overexpress her2.