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GSK-3β的生物学特性：GSK-3最早在兔 骨骼肌 的分次提取物中被分离出来，主要有两种亚型，即GSK-3α和GSK-3β，二者在催化区域具有98%的 同源性，于N-和C-末端略有不同. Here we summarize the structure and physiological functions of gsk3β and explore its involvement in ndds. 糖原合成酶激酶-3 (GSK-3)是一种在进化上非常保守的丝氨酸/苏氨酸激酶，能作用于众多信号蛋白、结构蛋白和转录因子，调节细胞的分化、增殖、存活和凋亡。

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Gsk3 refers to two paralogs that are commonly referred to as isoforms, gsk3α and gsk3β 糖原合酶激酶3 (GSK-3)是一个高度保守的蛋白激酶家族。 在人类中，两个基因编码两种不同但密切相关的GSK-3形式，称为 GSK-3α 和 GSK-3β。 A theoretical analysis found that gsk3β has more predicted substrates than any other kinase (linding et al., 2007).