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Discover what are the sources of pyrogens, the substances that cause fever The presence of pyrogens is a common trigger for inflammation and an integral part of innate nonspecific host defenses. Learn about endogenous and exogenous pyrogens, their origins in the body and environment, and their role in triggering the body's fever response.

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The host's response is mediated through the leukocytes (white blood corpuscles) which in turn release their own kind of pyrogen (endogenous pyrogen) and this in turn initiates the febrile. Pyrogens interact with the hypothalamus in the brain to raise the body's thermal set point, leading to fever Macrophages are stimulated by bacterial and viral infections to secrete chemicals called pyrogens

Whether endogenous (produced by the body) or exogenous (from external sources like bacteria or viruses), pyrogens trigger a cascade of immune responses that ultimately affect the hypothalamus, the part of the brain that regulates body temperature.

Either produced within the body or originating externally, that stimulate the immune system to induce fever as a defense mechanism against infections. Researchers in infectious diseases wanted to know about an endogenous protein that caused fever, independent of infection Granulocyte, endogenous or leukocytic pyrogen.