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When the cells are mononucleated, they are called hodgkin cells They release various cytokines and chemokines that attract other immune cells to the tumor microenvironment, leading to the characteristic inflammatory response observed in hodgkin lymphoma. This cancer usually forms in the lymph nodes in your neck or chest cavity

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But it can also appear in other lymph nodes throughout the body They are usually derived from b lymphocytes, classically considered crippled germinal center b cells.